Journal of Environmental Treatment Techniques  
2020, Volume 8, Issue 3, Pages: 1068-1074  
J. Environ. Treat. Tech.  
ISSN: 2309-1185  
Journal web link: http://www.jett.dormaj.com  
Evaluation of Biochemical Parameters in Type 1  
and Type 2 Diabetics in Rabat District of Morocco  
1
2
2
1
Miloudi Hilali *, Asmae Tantane , Mohamed Rhajaoui , Hanae El Monfalouti and Badr  
Eddine Kartah1  
1
Laboratory of Plant Chemistry and Organic and Bioorganic Synthesis, Faculty of Science, University Mohamed-V, Av Ibn Battouta, BP 1014 Agdal-  
Rabat, Morocco  
2
Laboratory biochemistry national institute of hygiene of Rabat, Morocco  
Received: 25/03/2020  
Accepted: 29/06/2020  
Published: 20/09/2020  
Abstract  
Diabetes represents a major public health problem and exposes to serious complications such as cardiovascular, renal, ocular,  
neurological diseases and sometimes wounds which are difficult to heal leading in the most extreme cases to amputation. The  
objective of this work is therefore to carry out an evaluation of certain biological parameters (fasting blood sugar, urea, total  
cholesterol, HDL, creatinine, uric acid), and hematological (white blood cells, red blood cells, platelets) in diabetic patients. the rabat-  
sale region and to find out which type of diabetic is the most distributed in this region so that in the end we will raise awareness among  
the entire population to make periodic analyzes in order to draw lessons and offer recommendations. The study of this work focused  
on 40 diabetic patients, including 8 type 1 diabetic patients and 32 type 2 diabetic patients. After that we took blood samples for  
biological analyzes. According to the study, we found that the number of type 2 diabetics (80%) is higher than that of type 1 diabetics  
(
(
20%), the number of women is greater than the number of men and the majority diabetic patients in our population are hypertensive  
70%). Our results also show that in type 2 diabetics the average rates of all parameters (fasting blood sugar, urea, creatinine and uric  
acid) are lower than those recorded in type 1 diabetics. Total cholesterol and HDL in type 2 diabetics are higher than those recorded in  
type 1 diabetics. This study shows that our patients do not have a problem of bacterial infection or rheumatism because almost all the  
values of creatinine, urea, uric acid, total cholesterol and the level of white blood cells are normal and also shows, the absence of  
cardiovascular and renal complications. But our study also showed that total cholesterol, urea and creatinine increase with age, and  
people between the ages of 60 and 75 are more at risk than others. The study of this work shows that the number of women who have  
diabetes is greater than the number of men and most of these people have chronic diseases, so to avoid serious complication on a  
health scale, we must therefore to sensitize and educate the populations to make periodic analyzes, to make sport activities and food  
rigime to finally reduce the rate of diabetic diseases.  
Keywords: Diabetes, Complications, Biochemical, Fasting glucose, Urea, Total cholesterol, HDL, Creatinine, Uric acid  
Introduction1  
of pregnant women [6]. It manifests itself as an increase in  
1
blood glucose towards the end of the 2nd and 3rd trimesters of  
pregnancy. In the majority of cases, it disappears after  
delivery. Diabetes is recognized today, supported by figures  
like a global epidemic and a tsunami whose human, social and  
economic consequences are devastating. In Morocco, the  
latest national figures exceed 10% for people over the age of  
Diabetes is a chronic disease that cannot be cured, but can  
be treated and controlled. It is caused by a lack or lack of use  
of a hormone called insulin. When there is a lack of insulin, or  
when it does not perform its function effectively, as is the case  
in a person with diabetes, glucose cannot be used as a fuel for  
cells. It then accumulates in the blood and causes an increase  
in sugar level (hyperglycemia). In the long run, high blood  
sugar causes complications, including eye, kidney, nerve,  
heart and blood vessel complications [1, 2].  
There are different types of diabetes: prediabetes, type 1  
diabetes, type 2 diabetes, gestational diabetes and other rarer  
types; Type 1 diabetes, accounts for 10 to 15% of diabetes  
cases [3]. It occurs most often in a non-obese subject before  
the age of 30 [4]. Diabetes type 2 known as fatty or mature  
diabetes, noninsulin-dependent diabetes mellitus (NIDDM) is  
a metabolic disorder characterized by chronic excess of blood  
sugar (hyperglycemia) [5]. The peripheral use of sugar in the  
cells: insulin, a hormone made by the pancreas, allows cells to  
collect and use glucose. Gestational Diabetes affects 3 to 20%  
2
0 years. And if we consider the age groups beyond 50 years,  
the prevalence exceeds 14%. Thus, today around two million  
people suffer from diabetes in our country [7]. diabetes is one  
of the worst health calamities in Morocco which costs  
millions of dirhams at the state coffers, each year, 500,000  
people at risk in primary health care establishments including  
people with a history 1st degree family (father or mother) with  
diabetes. Worse, almost 50% of all diabetics are unaware of  
their disease.  
Main objective of the study is concerned with three goals:  
(
a) to determine the distribution of diabetic patients by type of  
diabetes, sex, age and presence or absence of hypertension;  
b) a comparison of different biochemical parameters (fasting  
(